Volume No. 7 Issue No.: 2 Page No.: 720-723 Oct. - Dec. 2012

 

Short Communications (NS-2) CUTANEOUS SIDE EFFECTS OF SOME CHEMOTHERA- PEUTIC AGENTS IN THE MALE ALBINO RAT (Rattus norvegicus)

 

Sastry M.S.*, Gotmare V.V., Dighade S. W. and Kashmiri Z.N.

Department of Zoology, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur (INDIA)

 

Received on : July 05, 2012

 

ABSTRACT

 

Antineoplastic chemotherapies are widely used in many therapeutic protocols and are responsible for numerous cutaneous side effects. Much of the information recorded in the present study came from one decade study while studying the effects of some chemotherapeutic agents such as alkylating agents (cisplatin, carboplatin, oxaliplatin and cyclophosphamide); antimetabolite (methotrexate); plant alkaloids (vincristine and etoposide); anthracycline antibiotic (doxorubicin) on the male reproductive system and thyroid gland of rats. Some distinctive cutaneous side effects recorded were alopecia, hyper pigmentation, hypersensitivity reactions, photosensitivity, phlebitis, injection site reaction and thick dry skin, dryness, brittleness and ruffleness of hairs, nail changes, erythma, nail loss, pruritus (skin rash), ulceration, wound infection, skin necrosis, itching and allergic reaction. These side effects were dose and duration dependent and occurred in varying degree of frequency and severity with each class of chemotherapeutic drugs. Such studies would be useful to dermatologist, oncologist and in clinical management of oncology patients.

 

Keywords : Chemotherapeutic agents, Alopecia, Hyper pigmentation, Hypersensitivity

 

 

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