Volume No. 7 Issue No.: 1A Page No.: 267-274 July-September 2012


Glycerol as an Alternative Medium for Biocatalytic and Electrochemical Reduction of Benzoylpyridines


Sharma Shachi*, Sharma Jitender, Sharma Priyanka, Verma P.S. and Sharma I.K.

Department of Chemistry, University of Rajasthan, Jaipur, (INDIA)


Received on : April 05,2012




The paper reports the reduction of some benzoylpyridines through biocatalytic and electrochemical method using glycerol as an alternative green reaction medium. Bakerís yeast (Saccharomyces cerevisiae) was used for biocatalytic reduction of the substrates in aqueous-glycerol medium. Electrochemical behaviour of the substrates was investigated by cyclic voltammetry to establish optimum conditions for electrochemical reduction such as pH, solvent media, reduction potential range, supporting electrolyte etc. As a solvent, glycerol also allowed electro-reduction of the substrate, galvanostatically using economically viable stainless steel (SS–316) electrodes. The reduction products were isolated and purified by chromatographic techniques and characterized on the basis of spectral analysis.


Keywords : Benzoylpyridines, Bakerís Yeast (B.Y.), Biotransformation, Glycerol, Cyclic voltammetry, Stainless steel electrode (SS–316)