Volume No. 6 Issue No.: 3A Page No.: 738-742 Jan-Mar 12

 

ANTIBIOLOGICAL ACTIVITIES AND SPECTRAL STUDY OF PPIs WITH METALS

 

Chitra Rekha Tiwari

Department of Chemistry, Sagar Institute of Research and Technology, Bhopal, Madhya Pradesh (INDIA)

 

Received on : November 25, 2011

 

ABSTRACT

 

PPIs are first generation drugs. Pantoprazole (PAN) is one of the important PPI drug. PPIs play an important role to suppress the Gastric acid which is responsible for Peptic ulcer. Again, Metal complexes also play an important role in biological activities of drugs. In many cases metal complexes of drugs are more potent than the parent drug. Some physico-chemical properties are helpful in biological activities. Stepwise formation con- stant and corresponding values of free energy change of complexes of Pantoprazole (PAN an important antiul- cer drug, with transition metal ions [Vo(II), Cu(II) and Cd(II)] have been determined at 26°C and 36°C and 0.1M (NaNO3) ionic strength. Probable structures of isolated chelates have been assigned on the basis of IR and NMR spectral data. Antibacterial activities of the complexes "In vivo" for sensitivity test has been screened.

 

Keywords : Proton pump inhibitors (PPIs), Pantoprazole (PAN), Antibacterial activities, Sensitivity test , physico-chemical property

 

 

BACK