Volume No. 5 Issue No.: 3 Page No.: 551-557 January-March 2011

 

ANTICANCER ACTIVITY OF Cynodon dactylon L. EXTRACT ON EHRLICH ASCITES CARCINOMA

 

Krishnamoorthy M.* and Ashwini Prabhu

Department of Post graduate Studies and Research in Biosciences, Mangalore University, Mangalagangothri, Karnataka, (INDIA)

 

Received on : November 14, 2010

 

ABSTRACT

 

Cancer is the second leading cause of death worldwide next to cardiovascular diseases. Conventional therapies for treatment of cancer including chemotherapy and radiation therapy usually pose serious side effects. Use of herbal medicine for cancer treatment is gaining importance in this regard. India is a rich source of medicinal plants and a number of plant extracts are used against diseases in various medicinal systems. Cynodon dactylon L., (Family: Poaceae) commonly known as 'durva' grass is employed in India as a rejuvenator and for wound healing. In the present study, anticancer efficacy of Cynodon dactylon L. was assessed in Swiss albino mice Mus musculus. Mice inoculated with Ehrlich Ascites Carcinoma (EAC) cells were administered with three doses of Cynodon dactylon extract viz., 100, 200 and 400mg/kg body weight per oral for ten consecutive days. Anticancer activity of the extract was assessed based on Mean Survival Time (MST) and increase in life span (ILS) of experimental animals. In addition, hematological parameters like hemoglobin content, RBC count, WBC count and differential count of extract treated mice were also studied. Extract treatment enhanced the life span and restored the hematological parameters in EAC inoculated mice in comparison with tumor control group. Thus, the present study revealed that Cynodon dactylon L. extract showed significant anticancer activities in the tested animal models.

 

Keywords : Cynodon dactylon, Ehrlich Ascites Carcinoma, Swiss albino mice, Anticancer, Meon Survival Time (MST)

 

 

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