Volume No. 1 Issue No.: 3 Page No.: 247-250 January-March 2007

 

LEAD MODULATION ON ADOPTIVE IMMUNE RESPONSE IN MICE

 

R. Khanna

Department of Zoology, Govt. Girls P.G. College, Ujjain (India)

 

Received on : October 16, 2006

 

ABSTRACT

 

Recipient Swiss albino mice which received sensitized cells from peritoneal exudates (PEC), thymus (T) and bone marrow (BM) were exposed to lead and challenged with human dwarf tapeworm Hymenolepis nana. Oral lead exposure suppressed the immune response as indicated by low values of different fractions of immunoglobulins and increase in susceptibility to infection at larval and adult developmental stages in passively immunized mice. Both the humoral and cellular components of the immune system have failed to co-operate in the expulsion of worms but recients of sensitized T-cells showed lesser suppression of immune response in comparison to other recipient groups.

 

Keywords : Hymenolepis nana, Thymus (T), Peritoneal exudates (PEC), Bone marrow (BM), Adoptive immune response, Immunoglobulins, Worm recovery.

 

 

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