Volume No. 1 Issue No.: 2 Page No.: 148-150 October-December 200

 

SYNTHESIS AND PHARMACOLOGICAL SCREENING OF SOME BIODYNAMIC THIOSEMICARBAZONES AND ITS DERIVATIVES

 

A.K. Halve* Vasudha Sharma and Bhuwan Bhashkar

School of Studies in Chemistry, Jiwaji University, Gwalior (INDIA)

 

Received on : May 19, 2006

 

ABSTRACT

 

Thiosemicarbazones are found to be the new clinical candidates in the class of organic compounds. These compounds possess a wide range of biological activity depending on the parent aldehyde or ketone. It has also aroused considerable interest in chemistry and biology due to their wide spectrum of pharmacological activity. Besides the antimicrobial activity thiosemicarbazones have also been assessed for antitubercular, anticancer, anticonvulsants and anti-inflammatory activity hence find wide application in medicinal era. In light of these findings, some new thiosemicarbazones have been synthesized and screened for their in-vitro antimicrobial activity against various bacterial and fungal pathogens. Present communication reports the synthesis of a new series of thiosemicarbazones from thiosemicarbazide derivatives bearing potentially active pharmacophores. All the synthesized compounds have been screened in-vitro and have shown promising antimicrobial activity.

 

Keywords : Thiosemicarbazone, Antimicrobial activity, Biodynamic compounds, Thiosemicarbazide, In-vitro screening.

 

 

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