Volume No. 1 Issue No.: 2 Page No.: 121-123 October-December 200




Amit K. Jain* and Ajay K. Bose

Department of Chemistry and Chemical Biology, Stevens Institute of Technology; Hoboken; NJ; USA


Received on : June 20, 2006




Strategies for large-scale synthesis of physiologically active compounds are of great interest to pharmaceuticals companies. We have studied the energy picture of various synthetic reactions and concluded that a majority of them are exothermic when conducted under solvent-free conditions and it is unnecessary to provide energy to an exothermic reaction -except, when a small burst of energy may be needed to initiate the exothermic reaction proceeds on its own. An analogy is the use of a spark to start the burning of heap of hay for a long period. We wish to report here the intrinsic energy profile of widely used synthetic procedures, namely, the Knoevenagel reaction and its Doebner modification leading to substituted acrylic acids. In several cases a spontaneous reaction has been observed in our laboratory. This is an approach towards Green organic synthesis.


Keywords : Solvent free, Knoevenagel Condensation, Exothermic, Pharmaceuticals.