Volume No. 3 Issue No.: 1 Page No.: 257-268 July-Sept 2008




Ruhi Haque*, Mohini Saxena, Bhisham Yadav1, Mudrika Ahmed2

1. Advanced Materials and Processes Research Institute (CSIR), Bhopal (INDIA)
2. Chemistry Department, G.H. Raisoni Group of Institutions, Nagpur (INDIA)


Received on : April 8, 2008




Biodegradable polymer utilizes in various applications like natural packaging, paper coating, bio-plastics, films, bio-composites, in food processing and other disposable articles, as well as in biodegradable biomedical applications (tissue regeneration, implants and matrices for drug delivery devices). Aliphatic polyesters have tendency to biodegrade because ?-hydroxy-acids were obtained after enzymatic or hydrolytic cleavage, which in most cases are ultimately metabolized. Lactic acid has been an intermediate agent used in a wide range of industrial applications like food processing, cosmetics, pharmaceutical and biomedical. Lactic acid has received attention for use in a wide range of applications mostly as it acts as a monomer for the production of biodegradable poly (lactic acid) or polylactide (PLA). PLA can be produced chemically and biotechnologically but biotechnological routes are mostly favored because of environmental concerns and limited nature of petrochemical feedstocks. Worldwide efforts have been made for the production of lactic acid and PLA with good yield and low cost management. The details of raw material for lactic acid production, lactic acid producing microorganism, fermentation methodology, types of bioreactors used for the production of lactic acid, production yield of lactic acid, polymerization methods of PLA from lactic acid monomer and its recent application were discussed in this article.


Keywords : Biodegradable polymer; Polylactide polymer, Drug delivery, Microorganism, Raw material