Volume No. 3 Issue No.: 1 Page No.: 45-50 July-Sept 2008

 

MONITORING OF ENVIRONMENTAL POLLUTION THROUGH INCLUSION COMPLEX FORMATION: STUDY OF BENZATHINE PENCILLIN AND ?- CYCLODEXTRIN COMPLEX

 

Sunakar Panda and J.K. Tripathy*

Post Graduate Department, of Chemistry, Berhampur University, Bhanjabihar, Berhampur-7 Ganjam, Orissa, (INDIA)

 

Received on : March 4, 2008

 

ABSTRACT

 

Inclusion Complex formation is a methodology of monitoring emvironmental pollution. Benzathine Penicillin is a well known antibiotic for curing of a number of diseases like Rheumatic fever, Rheumatic pain etc. But due to its poor solubility in polar medium, the drug given to the patient is not effectively used. One of the ways to increase the solubility of the drug and to make it more efficient may be to form an inclusion complex with nontoxic ?-cyclodextrin which is an oligosaccharide appearing like a small hollow cylinder and have a tendency to form inclusion complex with a wide variety of guest molecules. In the present work, the inclusion complex of the drug has been synthesized with ?-cyclodextrin. The formation of inclusion complex is evident from increase in solubility in polar medium, change in spectral characteristics and change in pharmacological characteristics. In addition, thermodynamic properties of the inclusion complex have been studied.

 

Keywords : ?-cyclodextrin, Penicillin, Inclusion complex, Drug solubility

 

 

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