Volume No. 3 Issue No.: 1 Page No.: 37-44 July-Sept 2008

 

SYNTHESIS AND STUDIES OF MANNICH BASES OF 2-CHLORO 4-NITRO BENZAMIDE AS POTENTIAL ANTIMICROBIAL AGENT

 

Sheela Joshi*, Anju Das Manikpuri, Purti Bilgaiyan and Deepak Khare

School of Chemical Sciences, Devi Ahilya University, Khandwa Road, Indore, (INDIA)

 

Received on : March 6, 2008

 

ABSTRACT

 

The Mannich derivatives of 2-Chloro 4-nitrobenzamide with formaldehyde and various sulphonamide were synthesized for study of their biological effects. The structures of the synthesized compounds were assigned on the basis of elemental analyses, UV, IR and 1HNMR spectral studies. The biological screening of these synthesized compounds were done against E.coli and K.pneumoniae with a view to explore their antimicrobial action by disk diffusion method at 40,80 and 160mg/ml respectively. The results reveal the potential and importance of mounting new Mannich bases against pathogens under investigation and found to be low toxic as ascertained by LD50 test.

 

Keywords : 2chloro 4-nitrobenzamide, Sulphonamides, Mannich reaction, Mannich bases, Antimicrobial activity, Statistical analysis.

 

 

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