Volume No. 11 Issue No.: 4 Page No.: 712-723 April-June 2017

 

RISK FACTOR ANALYSIS OF CANCER TYPES, BRCA1 AND BRCA2 USING THE MATHEMATICAL MODELS : A REVIEW

 

Kamath Anusha, Alysia Apoorva, Mona V. and Manjunatha Reddy A. H.*

Department of Biotechnology, RV College of Engineering, Bengaluru, Karnataka (INDIA)

 

Received on : December 12, 2016

 

ABSTRACT

 

In order to determine the exact risk of cancer resulting from a mutation, genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 can help the clinical management of individuals with family history (FH) of the disease, by identifying individuals at highest risk. Those individuals can then be offered screening from an earlier age, prophylactic mastectomy or oophorectomy or potentially chemoprevention. It is important that genetic testing is targeted towards the individuals who are most likely to prove positive. Many of the models have been developed using the prior data to identify the genes responsible for the cancer at different stages. In this paper it is made to review the various methods followed to understand the disease causing genes, data analysis for the effective data modelling and the risk factors of the cancer. Name of the models have been discussed in the current publication with the advantages and limitations of each model.

 

Keywords : BRCA1, BRCA2, Genetic models, Mutation, Cancer

 

 

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