Volume No. 11 Issue No.: 1 Page No.: 156-168 July-September 2016

 

Review Paper (NS) CURCUMIN AND CURCUMINOIDS : THEIR CHEMISTRY, MECHANISM AND ACTIVITIES AS THERAPEUTIC AGENTS : A REVIEW

 

Bharadwaj S. Punita

Department of Chemistry, Shree J. P. Arts & Science College, Bharuch, Gujarat (INDIA)

 

Received on : April 06, 2016

 

ABSTRACT

 

Curcumin compounds can be found in many types of Curcuma Genus. Synthetic and natural curcumin compounds are demonstrated to have therapeutic potential as anti inflammatory , antioxidant , antiviral, antibacterial, anti infection, anti-allergy, anticancer and anti-HIV. Hence curcumin is a highly pleiotropic molecule capable of interacting with numerous molecular targets with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level. Among the curcuminoids, curcumin is the main and biologically targeted phytochemical. Curcumin [chemical name : (E,E)-1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6- heptadiene-3,5 dione] is a bis-?,?-unsaturated ?-diketone. Biological activities from curcumin derivatives are related to an extended conjugated double system prone to nucleophilic attack. The strength of the compound is affected by the substituent type and pattern that can be found in the aromatic ring. This review mainly focuses on the therapeutic potential of curcuminoids for various chronic diseases due to its anti-inflammatory and anti oxidative properties and an endeavor to clarify the mechanism. The mechanisms appear to involve the regulation of various molecular targets, including transcription factors (such as nuclear factor (NF)-?B), growth factors (such as vascular endothelial cell growth factor), inflammatory cytokines (such as tumor necrosis factor (TNF), interleukin (IL)), protein kinases (such as mammalian target of rapamycin, mitogen-activated protein kinases and Akt) and other enzymes such as cyclooxygenase (COX) and lipoxygenase (LOX). Results from completed clinical trials are encouraging and also confirm some of the mechanisms responsible for its efficacy.

 

Keywords : Curcumin, Curcuminoids, Anti-inflammatory, Anti oxidant, Anti cancer

 

 

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