Volume No. 8 Issue No.: 3A Page No.: 651-657 Jan-Mar 2014

 

LEAD EFFECT ON CELLULAR TRANSFER OF IMMUNE RESPONSE, MIGRATION INHIBITION FACTOR AND HUMORAL IMMUNITY

 

Khanna Rekha

Department of Zoology, Govt. Girls’ P.G. College, Ujjain (INDIA)

 

Received on : September 14, 2013

 

ABSTRACT

 

Lead is ubiquitous and causes number of disorders in body. Present investigations give evidence how lead interfere and modulate the defense mechanism. Subclinical doses of lead suppressed the immune response in mice infected with the human parasite – Hymenolepis nana. Lead exposed experimental animals and infected with H.nana showed persistence of immunosuppression for longer periods as indicated by worm retention in host beyond 100 days. Suppression of immune response in these mice is observed by serum electrophoretic analysis which showed low values of alpha, beta and gamma fractions reflecting reduction in protective antibodies like IgG, IgM and IgA. Also , infected mice showed enhancement of serum globulin fractions along with gradual cessation of suppressed immune response from day beyond 4 up to 100 , when experimental values are almost approaching normal. Our experiments give evidence that lead also suppressed MIF released by splenic leucocytes thus indicating its severe affects on T-cell dependent cellular immune reactions. The results indicate that immune dysfunction is a sensitive indicator of lead exposure.

 

Keywords : Lead exposure, Immunomodulation, Hymenolepis nana, Migration Inhibition Factor (MIF), Cellular immune reaction

 

 

BACK