Volume No. 9 Issue No.: 4 Page No.: 1189-1196 April June 2015

 

PLANTS WITH ANTI-Candida ACTIVITY AND THEIR MECHANISM OF ACTION : A REVIEW

 

Palande Vikrant, Jaitly Priya and Kunchiraman Bipinraj Nirichan*

Department Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth deemed University, Pune (INDIA)

 

Received on : January 22, 2015

 

ABSTRACT

 

Candida albicans is an opportunistic fungal pathogen of human present in mouth, skin, nails, mucous membranes of respiratory, gastrointestinal, female genital tract, etc. Vulvovaginal Candidiasis (VVC) is a common form of candidiasis seen in women, especially during the pregnancy and menstrual periods. Despite the high rate incidence, only limited number of therapy is available for this infection. Usually, VVC is treated by oral or topical anti-candida agents belonging to the category of fluoropyrimidines, polyenes, azoles and echinocandins. Inherent ability to react with other drugs restricted the use of fluoropyrimidines and polyenes, while most widely used drug, azoles, faces drug resistance by the pathogen. Even though, echinocandins are comparatively newer drug, there are reports of resistance against these groups in pathogenic Candida. This forces scientists to look for new form of drugs. Plants provide unlimited opportunities for new drug development because of the matchless availability of chemical diversity in the plant kingdom. Different bioactive secondary metabolites such as terpenoids, organosulfur compounds, isoquinoline alkaloid, flavonoids, fatty acids, lactone, naphthoquinone, phenolic compounds, etc. are distributed widely in various plant families. Many scientists have screened the ability of different plant species to inhibit Candida albicans and studied the mechanism of inhibition. This review compiles the names of reported plants, secondary metabolite present in them and mode of Candida inhibitory action of these compounds. Such a report would be useful for any drug discovery group to find out effective drug against pathogenic Candida.

 

Keywords : Candidiasis, Anticandida plants, Secondary metabolite, Pathogen, Phenolic compounds

 

 

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