Volume No. 9 Issue No.: 4 Page No.: 1133-1137 April June 2015

 

SYNTHESIS OF COVALENTLY CROSSLINKED CHITOSAN- STARCH COPOLYMERS THROUGH REACTIVE BLENDING FOR ORAL DRUG DELIVERY

 

Mewada R. K., Nimish Shah*1 and Mehta Tejal2

1. Department of Chemical Engineering, Institute of Technology, Nirma University, Ahmadabad (INDIA) 2. Department of Pharmaceutics, Institute of Pharmacy, Institute of Nirma University, Ahmadabad (INDIA)

 

Received on : January 25, 2015

 

ABSTRACT

 

Chitosan and starch are well-known biopolymers having wide range of applications in various fields. Their physical and chemical limitations make their application span narrow. In this work, covalently cross linked copolymers of chitosan (CHI) and starch (ST) are synthesized via reactive blending. The blends studied with Fourier Transform Infrared Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA) and Differential Thermal Analysis (DTA). Drug loaded tablets were prepared and drug release studied in acidic environment. The results suggest that starch- chitosan blend prolonged the release of drug through the matrix tablet.

 

Keywords : Controlled drug release, Reactive blending, Chitosan - starch blend, Chitosan - starch copolymer, FTIR

 

 

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