Volume No. 1 Issue No.: 1 Page No.: 1-4 July-September 2006

 

ENVIRONMENTALLY BENIGN, ENERGY EFFICIENT SYNTHESIS OF COUMARIN BY THE PECHMANN REACTION USING GRINDSTONE AND MICROWAVE "JUMP START" CHEMISTRY

 

Amit K. Jain*, Neha Carpenter and Ajay K. Bose

Department of Chemistry and Chemical Biology, Stevens Institute of Technology; Hoboken; NJ (USA)

 

Received on : May 03, 2006

 

ABSTRACT

 

The century old Pechmann reaction provides access to substituted coumarins by acid catalyzed interaction of phenols and ?-keto esters. This reaction under solvent free conditions is found to be exothermic. So it is unnecessary to provide energy in the form of heat for this type of reaction. Only a small burst of energy may be needed to initiate the reaction and the reaction proceeds on its own. An analogy is the use of a spark to start the burning of heap of hay for a long period. Therefore, Grindstone Chemistry involving friction activated exothermic reactions and Microwave "Jump Start" chemistry were found to be convenient for conducting Solvent-free Pechmann reactions. This is an effort towards the energy efficient eco-friendly synthesis of interesting organic molecules.

 

Keywords : Pechmann Reaction, Coumarin synthesis, Solvent-free reaction, Friction activated Reaction, Microwave "Jump Start"

 

 

BACK